MeSH Browser

MeSH Heading: ProTides
Tree Number(s): D13.695.623; D26.675.500
Unique ID: D000095802
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000095802
Scope Note: A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue.
Entry Term(s): Pro-Tide; Pro-Tides; ProTide; Prodrug Nucleotide; Prodrug Nucleotides
Registry Numbers: 0
Public MeSH Note: 2024
History Note: 2024
Date Introduced: 2024/01/01
Last Updated: 2024/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000758863
Registry Numbers: 0
Scope Note: A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue.
Terms: ProTides Preferred Term
Term UI T001125178
Date10/04/2022
LexicalTag NON
ThesaurusID NLM (2024); Prodrug Nucleotide
Term UI T001137898
Date06/02/2023
LexicalTag NON
ThesaurusID NLM (2024); Prodrug Nucleotides
Term UI T001137899
Date06/02/2023
LexicalTag NON
ThesaurusID NLM (2024); ProTide
Term UI T001125180
Date10/04/2022
LexicalTag NON
ThesaurusID NLM (2024); Pro-Tide
Term UI T001125181
Date10/04/2022
LexicalTag NON
ThesaurusID NLM (2024); Pro-Tides
Term UI T001125179
Date10/04/2022
LexicalTag NON
ThesaurusID NLM (2024)

ProTides MeSH Descriptor Data 2026