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Arachidonate 5-Lipoxygenase MeSH Descriptor Data 2022


MeSH Heading
Arachidonate 5-Lipoxygenase
Tree Number(s)
D08.811.682.690.416.583.500.055
D12.776.556.579.374.568.500.020
Unique ID
D001094
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D001094
Scope Note
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
Entry Term(s)
5-Lipoxygenase
Arachidonic Acid 5-Lipoxygenase
LTA4 Synthase
Leukotriene A Synthase
Leukotriene A4 Synthase
Leukotriene A4 Synthetase
Registry Number
EC 1.13.11.34
CAS Type 1 Name
Arachidonate:oxygen 5-oxidoreductase
Previous Indexing
Lipoxygenases (1974-1986)
Oxygenases (1966-1973)
Public MeSH Note
91; was see under ARACHIDONATE LIPOXYGENASES 1987-90
History Note
91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90
Entry Combination
antagonists & inhibitors:Lipoxygenase Inhibitors
Date Established
1991/01/01
Date of Entry
1986/06/16
Revision Date
2010/06/25
Arachidonate 5-Lipoxygenase Preferred
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