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Caffeine MeSH Descriptor Data 2024


MeSH Heading
Caffeine
Tree Number(s)
D03.132.960.175
D03.633.100.759.758.824.175
Unique ID
D002110
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002110
Scope Note
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Entry Term(s)
1,3,7-Trimethylxanthine
Caffedrine
Coffeinum N
Coffeinum Purrum
Dexitac
Durvitan
No Doz
Percoffedrinol N
Percutaféine
Quick-Pep
Vivarin
Pharm Action
Central Nervous System Stimulants
Phosphodiesterase Inhibitors
Purinergic P1 Receptor Antagonists
Related Numbers
58-08-2
CAS Type 1 Name
1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
NLM Classification #
QV 107
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2017/05/24
Caffeine Preferred
No Doz Narrower
Caffedrine Narrower
Coffeinum N Narrower
Coffeinum Purrum Narrower
Dexitac Narrower
Durvitan Narrower
Percoffedrinol N Narrower
Vivarin Narrower
Percutaféine Narrower
Quick-Pep Narrower
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