MeSH Browser

MeSH Heading: Cisplatin
Tree Number(s): D01.210.375; D01.625.125; D01.710.100
Unique ID: D002945
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002945
Scope Note: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Entry Term(s): Biocisplatinum; Dichlorodiammineplatinum; NSC-119875; Platidiam; Platino; Platinol; Platinum Diamminodichloride; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum
Pharm Action: Antineoplastic Agents
Cross-Linking Reagents
Radiation-Sensitizing Agents
Related Numbers: 15663-27-1
CAS Type 1 Name: Platinum, diamminedichloro-, (SP-4-2)-
NLM Classification #: QV 269
Previous Indexing: Amines (1966-1973); Ammonium Compounds (1966-1973); Chlorides (1966-1973); Platinum (1966-1973)
Public MeSH Note: 84; was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83
Online Note: use CISPLATIN to search PLATINUM DIAMMINODICHLORIDE 1974-80 & DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-83
History Note: 84(81); was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83
Date Established: 1984/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Inorganic Chemicals [D01]
- Chlorine Compounds [D01.210]

Inorganic Chemicals [D01]
- Nitrogen Compounds [D01.625]

Inorganic Chemicals [D01]
- Platinum Compounds [D01.710]
  - Cisplatin [D01.710.100]

Cisplatin Preferred

Concept UI: M0004505
Related Numbers: 15663-27-1
Scope Note: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Terms: Cisplatin Preferred Term
Term UI T008525
Date01/01/1999
LexicalTag NON
ThesaurusID; cis-Diamminedichloroplatinum
Term UI T008521
Date08/18/1980
LexicalTag NON
ThesaurusID; cis-Diamminedichloroplatinum(II)
Term UI T008522
Date03/04/1977
LexicalTag NON
ThesaurusID UNK (19XX); cis-Dichlorodiammineplatinum(II)
Term UI T008523
Date03/04/1977
LexicalTag NON
ThesaurusID UNK (19XX); cis-Platinum
Term UI T008524
Date08/18/1980
LexicalTag NON
ThesaurusID UNK (19XX); Dichlorodiammineplatinum
Term UI T008526
Date08/18/1980
LexicalTag NON
ThesaurusID UNK (19XX); Platinum Diamminodichloride
Term UI T008528
Date05/23/1980
LexicalTag NON
ThesaurusID UNK (19XX)

Biocisplatinum Narrower

Platidiam Narrower

Platino Narrower

Platinol Narrower

NSC-119875 Narrower

Cisplatin MeSH Descriptor Data 2024