MeSH Browser

MeSH Heading: Disulfiram
Tree Number(s): D02.241.081.251.869.220.250; D02.886.520.150.175; D02.886.706.200.200
Unique ID: D004221
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004221
Scope Note: A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Entry Term(s): Alcophobin; Antabus; Antabuse; Anticol; Bis(diethylthiocarbamoyl) Disulfide; Dicupral; Esperal; Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2; Tetraethylthiuram Disulfide; Teturam
Pharm Action: Alcohol Deterrents
Acetaldehyde Dehydrogenase Inhibitors
Related Numbers: 97-77-8
CAS Type 1 Name: Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0006600
Related Numbers: 97-77-8
Scope Note: A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Terms: Disulfiram Preferred Term
Term UI T012814
Date01/01/1999
LexicalTag NON
ThesaurusID; Tetraethylthiuram Disulfide
Term UI T012815
Date03/29/1974
LexicalTag NON
ThesaurusID; Bis(diethylthiocarbamoyl) Disulfide
Term UI T012816
Date07/31/1980
LexicalTag NON
ThesaurusID; Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
Term UI T012817
Date11/22/1993
LexicalTag NON
ThesaurusID NLM (1995)

Disulfiram MeSH Descriptor Data 2024