MeSH Browser

MeSH Heading: Glutamate-Cysteine Ligase
Tree Number(s): D08.811.464.259.850.400
Unique ID: D005721
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005721
Scope Note: One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
Entry Term(s): Glutamylcysteine Synthetase; gamma-Glutamyl-Cysteine Synthetase
Registry Number: EC 6.3.2.2
Related Numbers: 9023-64-7
CAS Type 1 Name: L-Glutamate:L-cysteine gamma-ligase (ADP-forming)
Previous Indexing: Cysteine (1973-1976); Glutamates (1973-1976); Peptide Synthetases (1973-1976)
Public MeSH Note: 98; see GAMMA-GLUTAMYL-CYSTEINE SYNTHETASE 1991-97; see PEPTIDE SYNTHETASES 1977-90
History Note: 98(77)
Date Established: 1991/01/01
Date of Entry: 1976/05/19
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0008975
Registry Number: EC 6.3.2.2
Related Numbers: 9023-64-7
Scope Note: One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
Terms: Glutamate-Cysteine Ligase Preferred Term
Term UI T017280
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); gamma-Glutamyl-Cysteine Synthetase
Term UI T017278
Date11/06/1996
LexicalTag NON
ThesaurusID NLM (1998); Glutamylcysteine Synthetase
Term UI T017279
Date02/08/1989
LexicalTag NON
ThesaurusID NLM (1989)

Glutamate-Cysteine Ligase MeSH Descriptor Data 2024