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Glucose-6-Phosphate Isomerase MeSH Descriptor Data 2023


MeSH Heading
Glucose-6-Phosphate Isomerase
Tree Number(s)
D08.811.399.475.200.350
Unique ID
D005956
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D005956
Scope Note
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Entry Term(s)
Autocrine Motility Factor
Glucosephosphate Isomerase
Isomerase, Glucose 6 Phosphate
Neuroleukin
Phosphoglucose Isomerase
Phosphohexose Isomerase
Tumor Autocrine Motility Factor
Tumor-Cell Autocrine Motility Factor
Registry Number
EC 5.3.1.9
Related Numbers
EC 5.3.1.9
CAS Type 1 Name
D-Glucose-6-phosphate ketol-isomerase
Public MeSH Note
1998; see GLUCOSEPHOSPHATE ISOMERASE 1965-1997; for AUTOCRINE MOTILITY FACTOR see AUTOCRINE MOTILITY FACTOR 1992-2011; for NEUROLEUKIN see NEUROLEUKIN 1990-2011
History Note
1998(1965)
Entry Combination
deficiency:Anemia, Hemolytic, Congenital Nonspherocytic
Date Established
1965/01/01
Date of Entry
1999/01/01
Revision Date
2019/07/01
Glucose-6-Phosphate Isomerase Preferred
Autocrine Motility Factor Narrower
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