MeSH Browser

MeSH Heading: Guanylyl Imidodiphosphate
Tree Number(s): D03.633.100.759.646.454.504.400; D13.695.667.454.504.400; D13.695.827.426.504.400
Unique ID: D006165
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006165
Scope Note: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
Entry Version: GPPNHP
Entry Term(s): GMP-P(NH)P; GMP-PNP; Gpp(NH)p; Guanosine 5'-(Beta,Gamma-Imido)Triphosphate; Guanyl-5'-Imidodiphosphate; P(NH)PPG
CAS Type 1 Name: 5'-Guanylic acid, monoanhydride with imidodiphosphoric acid
Previous Indexing: Guanine Nucleotides (1966-1977); Guanosine Triphosphate (1972-1977)
Public MeSH Note: 91; was see under GUANOSINE TRIPHOSPHATE 1978-90
History Note: 91(78); was see under GUANOSINE TRIPHOSPHATE 1978-90
Date Established: 1991/01/01
Date of Entry: 1977/04/22
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0009703
Scope Note: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
Terms: Guanylyl Imidodiphosphate Preferred Term
Term UI T018719
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Guanosine 5'-(Beta,Gamma-Imido)Triphosphate
Term UI T018717
Date10/27/1981
LexicalTag NON
ThesaurusID UNK (19XX); Guanyl-5'-Imidodiphosphate
Term UI T018718
Date08/30/1982
LexicalTag NON
ThesaurusID UNK (19XX); Gpp(NH)p
Term UI T018716
Date08/28/1981
LexicalTag ABB
ThesaurusID UNK (19XX); P(NH)PPG
Term UI T018720
Date07/28/1981
LexicalTag ABB
ThesaurusID UNK (19XX); GMP-P(NH)P
Term UI T018721
Date02/24/1998
LexicalTag ABB
ThesaurusID NLM (1999); GMP-PNP
Term UI T018722
Date02/24/1998
LexicalTag ABB
ThesaurusID NLM (1999)

Guanylyl Imidodiphosphate MeSH Descriptor Data 2024