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Guanylyl Imidodiphosphate MeSH Descriptor Data 2025
A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
Entry Version
GPPNHP
Entry Term(s)
GMP-P(NH)P
GMP-PNP
Gpp(NH)p
Guanosine 5'-(Beta,Gamma-Imido)Triphosphate
Guanyl-5'-Imidodiphosphate
P(NH)PPG
Registry Numbers
34273-04-6
CAS Type 1 Name
5'-Guanylic acid, monoanhydride with imidodiphosphoric acid
Previous Indexing
Guanine Nucleotides (1966-1977)
Guanosine Triphosphate (1972-1977)
Public MeSH Note
91; was see under GUANOSINE TRIPHOSPHATE 1978-90
History Note
91(78); was see under GUANOSINE TRIPHOSPHATE 1978-90
A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.