MeSH Browser

MeSH Heading: Monoamine Oxidase
Tree Number(s): D08.811.682.664.750
Unique ID: D008995
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008995
Scope Note: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Entry Term(s): Amine Oxidase (Flavin-Containing); MAO; MAO-A; MAO-B; Monoamine Oxidase A; Monoamine Oxidase B; Type A Monoamine Oxidase; Type B Monoamine Oxidase; Tyramine Oxidase
Registry Number: EC 1.4.3.4
Related Numbers: 9001-66-5
CAS Type 1 Name: Amine:oxygen oxidoreductase (deaminating) (flavin-containing)
NLM Classification #: QU 140
Public MeSH Note: 63; TYRAMINE OXIDASE was indexed under AMINE OXIDOREDUCTASES 1980-98
History Note: 63; for TYRAMINE OXIDASE use MONOAMINE OXIDASE (NM) 1980-98
Entry Combination: antagonists & inhibitors:Monoamine Oxidase Inhibitors
Date Established: 1963/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30

Entry Combination: antagonists & inhibitors:Monoamine Oxidase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxidoreductases Acting on CH-NH2 Group Donors [D08.811.682.664]

Monoamine Oxidase Preferred

Concept UI: M0014026
Registry Number: EC 1.4.3.4
Related Numbers: 9001-66-5
Scope Note: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Terms: Monoamine Oxidase Preferred Term
Term UI T026890
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Amine Oxidase (Flavin-Containing)
Term UI T026892
Date03/04/1994
LexicalTag NON
ThesaurusID NLM (1995); MAO
Term UI T026893
Date12/22/1997
LexicalTag ABB
ThesaurusID NLM (1999); Tyramine Oxidase
Term UI T026891
Date10/27/1997
LexicalTag NON
ThesaurusID NLM (1999)

Type A Monoamine Oxidase Narrower

Monoamine Oxidase B Narrower

Monoamine Oxidase MeSH Descriptor Data 2024