- Concept UI
- M0014877
- Registry Numbers
- 31C4KY9ESH
- Related Numbers
- 10102-43-9
- Scope Note
- A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
- Terms
-
Nitric Oxide
Preferred Term
Term UI
T028507
Date01/01/1999
LexicalTag
NON
ThesaurusID
-
Nitrogen Monoxide
Term UI
T028508
Date05/19/1981
LexicalTag
NON
ThesaurusID
-
Mononitrogen Monoxide
Term UI
T028510
Date02/24/1998
LexicalTag
NON
ThesaurusID
NLM (1999)
-
Endogenous Nitrate Vasodilator
Term UI
T046281
Date01/31/1989
LexicalTag
NON
ThesaurusID
NLM (1990)
-
Nitric Oxide, Endothelium-Derived
Term UI
T046285
Date02/25/1993
LexicalTag
NON
ThesaurusID
NLM (1994)