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Procollagen-Proline Dioxygenase MeSH Descriptor Data 2022


MeSH Heading
Procollagen-Proline Dioxygenase
Tree Number(s)
D08.811.682.690.416.617.750
D08.811.682.690.708.694.750
Unique ID
D011393
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011393
Scope Note
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
Entry Term(s)
Procollagen Prolyl 4-Hydroxylase
Protocollagen Prolyl Hydroxylase
Registry Number
EC 1.14.11.2
Related Numbers
9028-06-2
CAS Type 1 Name
Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase
Previous Indexing
Hydroxylases (1966-1971)
See Also
Protein Disulfide-Isomerases
Public MeSH Note
94; was PROLINE HYDROXYLASE 1974-93; PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93
Online Note
use PROCOLLAGEN-PROLINE DIOXYGENASE to search PROLINE HYDROXYLASE 1972-93 (as Prov 1972-73) & PROLINE,2-OXOGLUTARATE DIOXYGENASE 1977-93
History Note
94; was PROLINE HYDROXYLASE 1972-93 (Prov 1972-73); PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2013/07/08
Procollagen-Proline Dioxygenase Preferred
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