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Transglutaminases MeSH Descriptor Data 2022


MeSH Heading
Transglutaminases
Tree Number(s)
D08.811.913.050.200.800
Unique ID
D011503
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011503
Annotation
distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available
Scope Note
Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Entry Term(s)
Glutaminyl-Peptide Gamma-Glutamyltransferases
Protein-Glutamine gamma-Glutamyltransferases
Transglutaminase
Registry Number
EC 2.3.2.13
Related Numbers
80146-85-6
CAS Type 1 Name
Protein-glutamine:amine gamma-glutamyltransferase
Previous Indexing
Acyltransferases (1966-1985)
Public MeSH Note
2002; see PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 1986-2002; for TRANSGLUTAMINASES see TRANSGLUTAMINASES 1986-2002
History Note
2002(1986)
Date Established
1986/01/01
Date of Entry
1985/04/24
Revision Date
2020/05/27
Transglutaminases Preferred
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