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Pyroglobulins MeSH Descriptor Data 2023


MeSH Heading
Pyroglobulins
Tree Number(s)
D12.776.124.486.485.900.700
D12.776.124.790.651.900.700
D12.776.377.715.548.900.700
Unique ID
D011750
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011750
Scope Note
Atypical gamma immunoglobulins characterized by their irreversible heat denaturation at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive anaphylaxis and passive Arthus-type phenomena.
Pharm Action
Immunologic Factors
Registry Number
0
Previous Indexing
Heat (1972-1975)
Immunoglobulins (1972-1975)
Precipitation (1972-1975)
Public MeSH Note
91; was see under PARAPROTEINS 1976-90
History Note
91(76); was see under PARAPROTEINS 1976-90
Date Established
1991/01/01
Date of Entry
1975/08/01
Revision Date
2005/06/30
Pyroglobulins Preferred
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