- Concept UI
- M0018606
- Registry Numbers
- 0
- Scope Note
- Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
- Terms
-
Receptors, LDL
Preferred Term
Term UI
T035541
Date01/01/1999
LexicalTag
ACX
ThesaurusID
NLM (1985)
-
LDL Receptors
Term UI
T035540
Date05/25/1984
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
LDL Receptors, Lipoprotein
Term UI
T035533
Date05/25/1984
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
Lipoprotein LDL Receptors
Term UI
T035535
Date05/12/1992
LexicalTag
NON
ThesaurusID
NLM (1993)
-
LDL Receptor
Term UI
T035539
Date03/02/1993
LexicalTag
NON
ThesaurusID
NLM (1994)
-
Low Density Lipoprotein Receptors
Term UI
T035536
Date05/25/1984
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
Receptors, Lipoprotein, LDL
Term UI
T035534
Date05/25/1984
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
Receptors, Low Density Lipoprotein
Term UI
T035538
Date05/25/1984
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
Low Density Lipoprotein Receptor
Term UI
T035537
Date03/02/1993
LexicalTag
NON
ThesaurusID
NLM (1994)