MeSH Browser

MeSH Heading: Receptors, LDL
Tree Number(s): D12.776.543.750.710.450
Unique ID: D011973
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011973
Scope Note: Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Entry Version: RECEPT LDL
Entry Term(s): LDL Receptor; LDL Receptors; LDL Receptors, Lipoprotein; Lipoprotein LDL Receptors; Low Density Lipoprotein Receptor; Low Density Lipoprotein Receptors; Receptors, Lipoprotein, LDL; Receptors, Low Density Lipoprotein
NLM Classification #: QU 95
Previous Indexing: Lipoproteins, LDL (1972-1984); Receptors, Endogenous Substances (1973-1984)
See Also: Lipoproteins, LDL
Public MeSH Note: 85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92
Online Note: use RECEPTORS, LDL to search LIPOPROTEINS, LDL RECEPTORS 1985-92
History Note: 85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92
Date Established: 1985/01/01
Date of Entry: 1984/05/25
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Lipoprotein [D12.776.543.750.710]
        
        Receptors, LDL [D12.776.543.750.710.450]
        
        LDL-Receptor Related Proteins [D12.776.543.750.710.450.500]
        
        Receptors, Oxidized LDL [D12.776.543.750.710.450.625]
        
        Receptors, Scavenger [D12.776.543.750.710.450.750]

Receptors, LDL Preferred

Concept UI: M0018606
Scope Note: Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Terms: Receptors, LDL Preferred Term
Term UI T035541
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1985); LDL Receptors
Term UI T035540
Date05/25/1984
LexicalTag NON
ThesaurusID UNK (19XX); LDL Receptors, Lipoprotein
Term UI T035533
Date05/25/1984
LexicalTag NON
ThesaurusID UNK (19XX); Lipoprotein LDL Receptors
Term UI T035535
Date05/12/1992
LexicalTag NON
ThesaurusID NLM (1993); LDL Receptor
Term UI T035539
Date03/02/1993
LexicalTag NON
ThesaurusID NLM (1994); Low Density Lipoprotein Receptors
Term UI T035536
Date05/25/1984
LexicalTag NON
ThesaurusID UNK (19XX); Receptors, Lipoprotein, LDL
Term UI T035534
Date05/25/1984
LexicalTag NON
ThesaurusID UNK (19XX); Receptors, Low Density Lipoprotein
Term UI T035538
Date05/25/1984
LexicalTag NON
ThesaurusID UNK (19XX); Low Density Lipoprotein Receptor
Term UI T035537
Date03/02/1993
LexicalTag NON
ThesaurusID NLM (1994)

Receptors, LDL MeSH Descriptor Data 2024