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Phorbol 12,13-Dibutyrate MeSH Descriptor Data 2025


MeSH Heading
Phorbol 12,13-Dibutyrate
Tree Number(s)
D02.455.849.291.500.510.700
Unique ID
D015240
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015240
Scope Note
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
Entry Version
PDBU
Entry Term(s)
Phorbol-12,13-Dibutyrate
Pharm Action
Carcinogens
Registry Numbers
37558-16-0
CAS Type 1 Name
Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-
Previous Indexing
Phorbol Esters (1979-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/05/14
Revision Date
2004/07/30
Phorbol 12,13-Dibutyrate Preferred
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