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Transducin MeSH Descriptor Data 2024


MeSH Heading
Transducin
Tree Number(s)
D08.811.277.040.330.300.200.800
D12.776.157.325.332.940
D12.776.476.338.200.800
D12.776.543.325.800
Unique ID
D015293
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015293
Annotation
alpha, beta and gamma transducins refer to its subunits
Scope Note
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
Entry Term(s)
G-Protein, Inhibitory Gt
Gt, Transducin G-Protein
Transducin G-Protein (Gt)
Transducin, alpha Subunit
Transducin, beta Subunit
Transducin, gamma Subunit
alpha-Transducin
beta-Transducin
gamma-Transducin
Previous Indexing
Guanine Nucleotide Regulatory Protein (1985-1988)
Membrane Proteins (1980-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/05/24
Revision Date
2021/05/21
Transducin Preferred
alpha-Transducin Narrower
beta-Transducin Narrower
gamma-Transducin Narrower
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