MeSH Browser

MeSH Heading: Transducin
Tree Number(s): D08.811.277.040.330.300.200.800; D12.776.157.325.332.940; D12.776.476.338.200.800; D12.776.543.325.800
Unique ID: D015293
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015293
Annotation: alpha, beta and gamma transducins refer to its subunits
Scope Note: A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
Entry Term(s): G-Protein, Inhibitory Gt; Gt, Transducin G-Protein; Transducin G-Protein (Gt); Transducin, alpha Subunit; Transducin, beta Subunit; Transducin, gamma Subunit; alpha-Transducin; beta-Transducin; gamma-Transducin
Previous Indexing: Guanine Nucleotide Regulatory Protein (1985-1988); Membrane Proteins (1980-1988)
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/05/24
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0023545
Scope Note: A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
Terms: Transducin Preferred Term
Term UI T044946
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1989); G-Protein, Inhibitory Gt
Term UI T044947
Date03/06/1996
LexicalTag NON
ThesaurusID NLM (1997); Transducin G-Protein (Gt)
Term UI T044948
Date02/01/1996
LexicalTag NON
ThesaurusID NLM (1997); Gt, Transducin G-Protein
Term UI T044949
Date02/01/1996
LexicalTag NON
ThesaurusID NLM (1997)

Transducin MeSH Descriptor Data 2024