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Chloramphenicol O-Acetyltransferase MeSH Descriptor Data 2022


MeSH Heading
Chloramphenicol O-Acetyltransferase
Tree Number(s)
D08.811.913.050.134.170
Unique ID
D015500
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015500
Scope Note
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Entry Term(s)
CAT Enzyme
Chloramphenicol Acetyltransferase
Chloramphenicol Transacetylase
Registry Number
EC 2.3.1.28
Related Numbers
9040-07-7
CAS Type 1 Name
Acetyl-CoA-chloramphenicol 3-O-acetyltransferase
Previous Indexing
Acetyltransferases (1973-1988)
Transferases (1966-1972)
See Also
Chloramphenicol Resistance
Public MeSH Note
1998; see CHLORAMPHENICOL ACETYLTRANSFERASE 1989-1997
History Note
1998(1989)
Date Established
1989/01/01
Date of Entry
1988/07/13
Revision Date
2019/07/01
Chloramphenicol O-Acetyltransferase Preferred
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