MeSH Browser

MeSH Heading: Chloramphenicol O-Acetyltransferase
Tree Number(s): D08.811.913.050.134.170
Unique ID: D015500
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015500
Scope Note: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Entry Term(s): CAT Enzyme; Chloramphenicol Acetyltransferase; Chloramphenicol Transacetylase
Related Numbers: 9040-07-7
CAS Type 1 Name: Acetyl-CoA-chloramphenicol 3-O-acetyltransferase
Previous Indexing: Acetyltransferases (1973-1988); Transferases (1966-1972)
See Also: Chloramphenicol Resistance
Public MeSH Note: 1998; see CHLORAMPHENICOL ACETYLTRANSFERASE 1989-1997
History Note: 1998(1989)
Date Established: 1989/01/01
Date of Entry: 1988/07/13
Revision Date: 2019/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0023862
Related Numbers: 9040-07-7
Scope Note: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Terms: Chloramphenicol O-Acetyltransferase Preferred Term
Term UI T045977
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1989); CAT Enzyme
Term UI T045974
Date05/24/1988
LexicalTag NON
ThesaurusID UNK (19XX); Chloramphenicol Acetyltransferase
Term UI T045975
Date12/03/1996
LexicalTag NON
ThesaurusID NLM (1998); Chloramphenicol Transacetylase
Term UI T045976
Date05/24/1988
LexicalTag NON
ThesaurusID UNK (19XX)

Chloramphenicol O-Acetyltransferase MeSH Descriptor Data 2024