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2-Amino-5-phosphonovalerate MeSH Descriptor Data 2022


MeSH Heading
2-Amino-5-phosphonovalerate
Tree Number(s)
D12.125.070.950.100
D12.125.740.025
Unique ID
D015763
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015763
Scope Note
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Entry Term(s)
2-APV
2-Amino-5-phosphonopentanoate
2-Amino-5-phosphonopentanoic Acid
2-Amino-5-phosphonovaleric Acid
5-Phosphononorvaline
d-APV
dl-APV
Pharm Action
Excitatory Amino Acid Antagonists
Registry Number
76726-92-6
CAS Type 1 Name
Norvaline, 5-phosphono-
Previous Indexing
Anticonvulsants (1966-1989)
Valine (1966-1974)
Valine/analogs & derivatives (1975-1989)
Public MeSH Note
90
History Note
90
Date Established
1990/01/01
Date of Entry
1989/05/25
Revision Date
2007/07/09
2-Amino-5-phosphonovalerate Preferred
dl-APV Related
d-APV Related
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