NLM Logo

Factor VIIIa MeSH Descriptor Data 2023


MeSH Heading
Factor VIIIa
Tree Number(s)
D12.776.124.125.350.300
D23.119.350.300
Unique ID
D015944
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015944
Scope Note
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Entry Term(s)
Blood Coagulation Factor VIII, Activated
Coagulation Factor VIIIa
Factor 8A
Factor Eight A
Factor VIII, Activated
Factor VIII, Thrombin-Activated
Factor VIIIa Heavy Chain, 200 kDa Isoform
Factor VIIIa Heavy Chain, 92 kDa Isoform
Factor VIIIa Light Chain
Registry Number
72175-66-7
CAS Type 1 Name
Blood-coagulation factor VIIIa, procoagulant
Previous Indexing
Factor VIII (1981-1989)
See Also
Coagulants
Public MeSH Note
90
History Note
90
Entry Combination
deficiency:Hemophilia A
Date Established
1990/01/01
Date of Entry
1989/05/25
Revision Date
2019/05/30
Factor VIIIa Preferred
Factor VIIIa Heavy Chain, 92 kDa Isoform Narrower
Factor VIIIa Light Chain Narrower
Factor VIIIa Heavy Chain, 200 kDa Isoform Narrower
page delivered in 0.19s