MeSH Browser

MeSH Heading: Methacholine Chloride
Tree Number(s): D02.092.877.883.555.500; D02.675.276.534.500
Unique ID: D016210
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016210
Scope Note: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Entry Term(s): 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride; Acetyl-2-methylcholine Chloride; Acetyl-beta-methacholine Chloride; Acetyl-beta-methylcholine; Mecholine; Mecholyl; Methacholine; Provocholine; Provokit
Pharm Action: Miotics
Parasympathomimetics
Bronchoconstrictor Agents
Muscarinic Agonists
Registry Numbers: 0W5ETF9M2K; 0; 03V657ZD3V
Related Numbers: 03V657ZD3V; 55-92-5; 62-51-1
CAS Type 1 Name: 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride
Previous Indexing: Methacholine Compounds (1966-1990)
Public MeSH Note: 91
History Note: 91
Date Established: 1991/01/01
Date of Entry: 1990/04/24
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0024753
Registry Numbers: 0W5ETF9M2K
Related Numbers: 03V657ZD3V; 55-92-5; 62-51-1
Scope Note: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Terms: Methacholine Chloride Preferred Term
Term UI T048229
Date01/01/1999
LexicalTag NON
ThesaurusID; Acetyl-2-methylcholine Chloride
Term UI T048227
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); Acetyl-beta-methacholine Chloride
Term UI T048228
Date03/19/1990
LexicalTag NON
ThesaurusID NLM (1991); 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
Term UI T048230
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Mecholine
Term UI T048232
Date11/26/1996
LexicalTag NON
ThesaurusID NLM (1998)

Methacholine Chloride MeSH Descriptor Data 2025