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Leukocyte Common Antigens MeSH Descriptor Data 2023


MeSH Heading
Leukocyte Common Antigens
Tree Number(s)
D08.811.277.352.650.775.400.100.500
D12.776.476.564.400.100.500
D12.776.543.733.937.500
Unique ID
D017493
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D017493
Scope Note
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Entry Term(s)
2H4 Antigens
Antigens, CD45
B220 Antigen
B220 Antigens
CD45 Antigen
CD45 Antigens
CD45R Antigens
CD45R0 Antigens
CD45RA Antigens
CD45RB Antigens
CD45RCAntigens
CD45RO Antigens
L-CA Antigens
Leukocyte Common Antigen
Protein Tyrosine Phosphatase, Receptor Type, C
T200 Antigens
Registry Number
EC 3.1.3.48
Previous Indexing
Antigens, CD (1989-1992)
Antigens, Differentiation (1984-1991)
Histocompatibility Antigens (1984-1992)
Public MeSH Note
2018; see ANTIGENS, CD45 1993-2017 and CD45 ANTIGEN 1984-1992; CD45 ANTIGEN was indexed under ANTIGENS, CD 1989-92 and HISTOCOMPATIBILITY ANTIGENS & ANTIGENS, DIFFERENTIATION 1984-92; RT7 ANTIGEN was indexed under HISTOCOMPATIBILITY ANTIGENS 1983-92; B220 ANTIGEN was indexed under ANTIGENS, SURFACE 1990-95
History Note
2018 (1993); for RT7 use HISTOCOMPATIBILITY ANTIGENS RT 1983-92; for B220 ANTIGEN use ANTIGENS, CD45 1990-95
Date Established
1993/01/01
Date of Entry
1992/05/13
Revision Date
2021/05/21
Leukocyte Common Antigens Preferred
CD45RO Antigens Related
CD45RB Antigens Narrower
CD45RCAntigens Narrower
B220 Antigens Narrower
CD45RA Antigens Narrower
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