MeSH Browser

MeSH Heading: Phosphatidylinositol 4,5-Diphosphate
Tree Number(s): D10.570.755.375.760.400.942.625.900
Unique ID: D019269
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019269
Scope Note: A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
Entry Term(s): Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol Phosphate, PtdIns(4,5)P2; Phosphatidylinositol-4,5-Biphosphate; PtIns 4,5-P2; PtdIns(4,5)P2; PtdInsP; PtdInsP2
Registry Numbers: 0
Previous Indexing: Phosphatidylinositol Phosphates (1994-1996); Phosphatidylinositols (1981-1993)
Public MeSH Note: 97; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE was indexed under PHOSPHATIDYLINOSITOL PHOSPHATES 1994-96 & PHOSPHOINOSITIDES 1981-93
Online Note: use PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE (NM) to search PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE 1981-96
History Note: 97; see PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE (NM) 1981-96
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2010/06/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0028698
Registry Numbers: 0
Scope Note: A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
Terms: Phosphatidylinositol 4,5-Diphosphate Preferred Term
Term UI T057407
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1997); Phosphatidylinositol 4,5-Biphosphate
Term UI T057410
Date11/24/1995
LexicalTag NON
ThesaurusID NLM (1997); Phosphatidylinositol Phosphate, PtdIns(4,5)P2
Term UI T768881
Date04/07/2010
LexicalTag NON
ThesaurusID NLM (2011); Phosphatidylinositol-4,5-Biphosphate
Term UI T768882
Date04/07/2010
LexicalTag NON
ThesaurusID NLM (2011); PtdIns(4,5)P2
Term UI T477234
Date01/12/2002
LexicalTag NON
ThesaurusID NLM (2011); PtdInsP2
Term UI T057412
Date01/13/1997
LexicalTag ABB
ThesaurusID NLM (1998); PtdInsP
Term UI T762544
Date12/16/2009
LexicalTag NON
ThesaurusID NLM (2011); PtIns 4,5-P2
Term UI T057411
Date11/24/1995
LexicalTag ABB
ThesaurusID NLM (1997)

Phosphatidylinositol 4,5-Diphosphate MeSH Descriptor Data 2024