A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
Entry Term(s)
12-HETE
12-R-HETE
12-S-HETE
12-S-Hydroxyeicosatetraenoic Acid
Registry Number
59985-28-3
Previous Indexing
Arachidonic Acids (1975-1984)
Fatty Alcohols (1975-1976)
Hydroxy Acids (1976-1978)
Hydroxyeicosatetraenoic Acids (1985-1996)
Public MeSH Note
97; 12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID was indexed under HYDROXYEICOSATETRAENOIC ACIDS 1985-96, ARACHIDONIC ACIDS 1975-84, HYDROXY ACIDS 1976-80, & FATTY ALCOHOLS 1975-76
Online Note
use 12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID (NM) to search 12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID 1980-96
History Note
97; was 12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID (NM) 1975-96
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
