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Neuropil Threads MeSH Descriptor Data 2022


MeSH Heading
Neuropil Threads
Tree Number(s)
A08.637.500.550
A08.675.703.550
A11.284.430.214.190.750.602.620
A11.650.500.550
A11.671.685.550
Unique ID
D019600
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019600
Annotation
do not confuse with NEUROPIL, a "felt" of interwoven neuronal components & neuroglia
Scope Note
Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
Public MeSH Note
98
History Note
98
Date Established
1998/01/01
Date of Entry
1997/06/20
Revision Date
2012/09/27
Neuropil Threads Preferred
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