NLM Logo

Tissue Inhibitor of Metalloproteinase-2 MeSH Descriptor Data 2024


MeSH Heading
Tissue Inhibitor of Metalloproteinase-2
Tree Number(s)
D12.776.815.875.500
Unique ID
D019716
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019716
Scope Note
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Entry Version
TISSUE INHIB METALLOPROTEINASE 2
Entry Term(s)
TIMP-2
Pharm Action
Matrix Metalloproteinase Inhibitors
Registry Number
127497-59-0
Previous Indexing
Neoplasm Proteins (1989-1993)
Proteins (1990-1997)
Public MeSH Note
1998; TISSUE INHIBITOR OF METALLOPROTEINASE 2 was indexed under PROTEINS 1990-97 & NEOPLASM PROTEINS 1989-1993
History Note
1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997
Date Established
1998/01/01
Date of Entry
1997/06/30
Revision Date
2022/07/12
Tissue Inhibitor of Metalloproteinase-2 Preferred
page delivered in 0.149s