MeSH Browser

MeSH Heading: 2,3-Diphosphoglycerate
Tree Number(s): D02.241.081.844.387.388.175; D02.241.511.902.387.388.175; D02.705.400.140.175; D09.811.366.388.175
Unique ID: D019794
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019794
Scope Note: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Entry Term(s): 2,3-Bisphosphoglycerate; 2,3-DPG; 2,3-Diphosphoglycerate, (D)-Isomer; 2,3-Diphosphoglyceric Acid; Glycerate 2,3-Bisphosphate
Registry Numbers: 138-81-8; 0; 14438-19-8
Related Numbers: 14438-19-8
Previous Indexing: Diphosphoglyceric Acids (1980-1997)
Public MeSH Note: 98; 2,3-DIPHOSPHOGLYCERATE was indexed under DIPHOSPHOGLYCERIC ACIDS 1980-97
History Note: 98; use 2,3-DIPHOSPHOGLYCERATE (NM) 1980-97
Entry Combination: analogs & derivatives:Diphosphoglyceric Acids
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2012/07/03

Entry Combination: analogs & derivatives:Diphosphoglyceric Acids
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0029370
Registry Numbers: 138-81-8
Related Numbers: 14438-19-8
Scope Note: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Terms: 2,3-Diphosphoglycerate Preferred Term
Term UI T058869
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1998); 2,3-Bisphosphoglycerate
Term UI T058870
Date12/18/1996
LexicalTag NON
ThesaurusID NLM (1998); Glycerate 2,3-Bisphosphate
Term UI T058872
Date12/26/1996
LexicalTag NON
ThesaurusID NLM (1998); 2,3-DPG
Term UI T058871
Date12/20/1996
LexicalTag ABB
ThesaurusID NLM (1998)

2,3-Diphosphoglycerate MeSH Descriptor Data 2025