MeSH Browser

MeSH Heading: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Tree Number(s): D01.248.497.158.685.750.744.650.500.500; D01.339.431.374.744.650.500.500; D01.650.550.750.700.650.500.500; D02.389.593.374.744.650.500.500; D10.251.355.255.550.025.650.500.500; D23.469.050.175.725.025.650.500.500; D23.469.700.630.500
Unique ID: D019796
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019796
Scope Note: A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
Entry Term(s): (15S)-Hydroxy-11 alpha, 9 alpha-(epoxymethano)prosta-5Z, 13E-dienoic Acid; (15S)hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid; 11 alpha,9 alpha-Epoxymethano PGH2; 9,11-Dideoxy-11 alpha,9 alpha-epoxymethanoprostaglandin F2 alpha; 9,11-Dideoxy-11 alpha,9-alpha-epoxymethano-PGF2 alpha; 9,11-epoxymethano-PGH2; U-44619; U-46619; U44619; U46619
Pharm Action: Vasoconstrictor Agents
Related Numbers: 56985-40-1-isomer; 72580-47-3-isomer; 87421-95-2-isomer
CAS Type 1 Name: 5-Heptenoic Acid, 7-(6-(3-Hydroxy-1-Ocentyl)-2-Oxabicyclo(2.2.1)hept-5-yl)-, (1R-(1alpha,4alpha,5 beta(Z),6alpha(1E,3S*)))-
Previous Indexing: Prostaglandin Endoperoxides, Synthetic (1978-1997); Thromboxane A2/analogs & derivatives (1983-1997)
Public MeSH Note: 1998; 15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID was indexed under PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC 1978-97 & THROMBOXANE A2/analogs & derivatives 1983-97; (15S)HYDROXY-9ALPHA,11ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID and 9,11-EPOXYMETHANO-PGH2 were indexed under PROSTAGLANDINS H 1993-2003 & PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC 1986-1992
History Note: 1998; use 15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID (NM) 1977-1997; for (15S)HYDROXY-9ALPHA,11ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID and 9,11-EPOXYMETHANO-PGH2 use PROSTAGLANDIN H2 (NM) 1992-2003
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2023/02/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Inorganic Chemicals [D01]
- Electrolytes [D01.248]
  - Ions [D01.248.497]
    - Anions [D01.248.497.158]
      - Oxides [D01.248.497.158.685]
        
        Peroxides [D01.248.497.158.685.750]
        
        Prostaglandin Endoperoxides [D01.248.497.158.685.750.744]
        
        Prostaglandins H [D01.248.497.158.685.750.744.650]
        
        Prostaglandin H2 [D01.248.497.158.685.750.744.650.500]
        
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid [D01.248.497.158.685.750.744.650.500.500]

Inorganic Chemicals [D01]
- Free Radicals [D01.339]
  - Reactive Oxygen Species [D01.339.431]
    - Peroxides [D01.339.431.374]
      - Prostaglandin Endoperoxides [D01.339.431.374.744]
        
        Prostaglandins H [D01.339.431.374.744.650]
        
        Prostaglandin H2 [D01.339.431.374.744.650.500]
        
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid [D01.339.431.374.744.650.500.500]

Inorganic Chemicals [D01]
- Oxygen Compounds [D01.650]
  - Oxides [D01.650.550]
    - Peroxides [D01.650.550.750]
      - Prostaglandin Endoperoxides [D01.650.550.750.700]
        
        Prostaglandins H [D01.650.550.750.700.650]
        
        Prostaglandin H2 [D01.650.550.750.700.650.500]
        
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid [D01.650.550.750.700.650.500.500]

Organic Chemicals [D02]
- Free Radicals [D02.389]
  - Reactive Oxygen Species [D02.389.593]
    - Peroxides [D02.389.593.374]
      - Prostaglandin Endoperoxides [D02.389.593.374.744]
        
        Prostaglandins H [D02.389.593.374.744.650]
        
        Prostaglandin H2 [D02.389.593.374.744.650.500]
        
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid [D02.389.593.374.744.650.500.500]

Lipids [D10]
- Fatty Acids [D10.251]
  - Fatty Acids, Unsaturated [D10.251.355]
    - Eicosanoids [D10.251.355.255]
      - Prostaglandins [D10.251.355.255.550]
        
        Prostaglandin Endoperoxides [D10.251.355.255.550.025]
        
        Prostaglandins H [D10.251.355.255.550.025.650]
        
        Prostaglandin H2 [D10.251.355.255.550.025.650.500]
        
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid [D10.251.355.255.550.025.650.500.500]

Biological Factors [D23]
- Inflammation Mediators [D23.469]
  - Autacoids [D23.469.050]
    - Eicosanoids [D23.469.050.175]
      - Prostaglandins [D23.469.050.175.725]
        
        Prostaglandin Endoperoxides [D23.469.050.175.725.025]
        
        Prostaglandins H [D23.469.050.175.725.025.650]
        
        Prostaglandin H2 [D23.469.050.175.725.025.650.500]
        
        15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid [D23.469.050.175.725.025.650.500.500]

Biological Factors [D23]
- Inflammation Mediators [D23.469]
  - Prostaglandins, Synthetic [D23.469.700]
    - Prostaglandin Endoperoxides, Synthetic [D23.469.700.630]
      - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid [D23.469.700.630.500]

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Preferred

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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid MeSH Descriptor Data 2024