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Conotoxins MeSH Descriptor Data 2022


MeSH Heading
Conotoxins
Tree Number(s)
D20.888.590.162
D23.946.580.590.162
D23.946.833.590.162
Unique ID
D020916
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020916
Annotation
OMEGA-CONOTOXINS and OMEGA-CONOTOXIN GVIA are available
Scope Note
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Entry Term(s)
Conotoxin
alpha-Conotoxin
alpha-Conotoxins
mu-Conotoxin
mu-Conotoxins
Pharm Action
Calcium Channel Blockers
Neurotoxins
Registry Number
0
Previous Indexing
Mollusk Venoms (1986-1999)
Public MeSH Note
2000
History Note
2000
Date Established
2000/01/01
Date of Entry
1999/11/03
Revision Date
2005/06/30
Conotoxins Preferred
mu-Conotoxins Narrower
alpha-Conotoxins Narrower
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