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HMG-Box Domains MeSH Descriptor Data 2025


MeSH Heading
HMG-Box Domains
Tree Number(s)
G02.111.570.820.709.275.750.235
Unique ID
D024742
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D024742
Annotation
HIGH MOBILITY GROUP PROTEINS is also available
Scope Note
DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)
Entry Term(s)
HMG-1-Box Domain
HMG-Box Domain
High Mobility Group-Box Domains
Previous Indexing
High Mobility Group Proteins (1991-2001)
Public MeSH Note
2002
History Note
2002
Date Established
2002/01/01
Date of Entry
2001/08/03
Revision Date
2016/05/31
HMG-Box Domains Preferred
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