MeSH Browser

MeSH Heading: alpha Karyopherins
Tree Number(s): D12.776.157.530.750.500.100; D12.776.543.585.750.500.100; D12.776.660.502.100
Unique ID: D028901
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D028901
Scope Note: Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Entry Term(s): Importin-alpha; Karyopherin alpha; NLS Receptor; NLS-Binding Protein; NLSBP; Nuclear Localization Sequence Receptor; Nuclear Localization Signal-Binding Protein
Previous Indexing: Nuclear Proteins (1994-2001)
See Also: Nuclear Localization Signals
Public MeSH Note: 2002; KARYOPHERIN ALPHA (now ALPHA KARYOPHERINS) was indexed under NUCLEAR PROTEINS 1994-2001; IMPORTIN-ALPHA was indexed under NUCLEAR PROTEINS 1995-2001; NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN were indexed under NUCLEAR PROTEINS & PHOSPHOPROTEINS 1992-2001
History Note: 2002; use ALPHA KARYOPHERINS (NM) 1994-2001; for IMPORTIN-ALPHA use KARYOPHERINS 1995-2001; for NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN use NOPP140 (NM) 1992-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2005/07/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Nucleocytoplasmic Transport Proteins [D12.776.157.530.750]
        
        Karyopherins [D12.776.157.530.750.500]
        
        alpha Karyopherins [D12.776.157.530.750.500.100]
        
        beta Karyopherins [D12.776.157.530.750.500.249]
        
        Exportin 1 Protein [D12.776.157.530.750.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Nucleocytoplasmic Transport Proteins [D12.776.543.585.750]
        
        Karyopherins [D12.776.543.585.750.500]
        
        alpha Karyopherins [D12.776.543.585.750.500.100]
        
        beta Karyopherins [D12.776.543.585.750.500.249]
        
        Exportin 1 Protein [D12.776.543.585.750.500.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Karyopherins [D12.776.660.502]

alpha Karyopherins Preferred

Concept UI: M0240469
Scope Note: Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Terms: alpha Karyopherins Preferred Term
Term UI T443992
Date04/24/2001
LexicalTag NON
ThesaurusID NLM (2002); Importin-alpha
Term UI T270474
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Karyopherin alpha
Term UI T262921
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); NLS Receptor
Term UI T262914
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); NLS-Binding Protein
Term UI T233568
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); NLSBP
Term UI T233569
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Nuclear Localization Sequence Receptor
Term UI T262923
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Nuclear Localization Signal-Binding Protein
Term UI T233572
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002)

alpha Karyopherins MeSH Descriptor Data 2024