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alpha Karyopherins MeSH Descriptor Data 2025


MeSH Heading
alpha Karyopherins
Tree Number(s)
D12.776.157.530.750.500.100
D12.776.543.585.750.500.100
D12.776.660.502.100
Unique ID
D028901
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D028901
Scope Note
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Entry Term(s)
Importin-alpha
Karyopherin alpha
NLS Receptor
NLS-Binding Protein
NLSBP
Nuclear Localization Sequence Receptor
Nuclear Localization Signal-Binding Protein
Registry Numbers
0
Previous Indexing
Nuclear Proteins (1994-2001)
See Also
Nuclear Localization Signals
Public MeSH Note
2002; KARYOPHERIN ALPHA (now ALPHA KARYOPHERINS) was indexed under NUCLEAR PROTEINS 1994-2001; IMPORTIN-ALPHA was indexed under NUCLEAR PROTEINS 1995-2001; NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN were indexed under NUCLEAR PROTEINS & PHOSPHOPROTEINS 1992-2001
History Note
2002; use ALPHA KARYOPHERINS (NM) 1994-2001; for IMPORTIN-ALPHA use KARYOPHERINS 1995-2001; for NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN use NOPP140 (NM) 1992-2001
Date Established
2002/01/01
Date of Entry
2001/07/25
Revision Date
2005/07/12
alpha Karyopherins Preferred
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