MeSH Browser

MeSH Heading: 4-Quinolones
Tree Number(s): D03.633.100.810.835.830
Unique ID: D042462
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D042462
Scope Note: QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
Entry Term(s): 4-Oxoquinoline; 4-Oxoquinolines; 4-Quinolinone; 4-Quinolinones; 4-Quinolone
Public MeSH Note: 2004
History Note: 2004
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0441453
Scope Note: QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
Terms: 4-Quinolones Preferred Term
Term UI T525313
Date11/05/2002
LexicalTag NON
ThesaurusID NLM (2004); 4-Quinolone
Term UI T000998549
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); 4-Quinolinone
Term UI T000998550
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); 4-Oxoquinolines
Term UI T699145
Date06/06/2007
LexicalTag NON
ThesaurusID NLM (2008); 4-Quinolinones
Term UI T699146
Date06/06/2007
LexicalTag NON
ThesaurusID NLM (2008); 4-Oxoquinoline
Term UI T000998548
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021)

4-Quinolones MeSH Descriptor Data 2024