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1-Alkyl-2-acetylglycerophosphocholine Esterase MeSH Descriptor Data 2022


MeSH Heading
1-Alkyl-2-acetylglycerophosphocholine Esterase
Tree Number(s)
D08.811.277.352.100.680.750.937.249
Unique ID
D043203
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D043203
Annotation
/antag: coordinate with PHOSPHOLIPASE A2 INHIBITORS
Scope Note
A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Entry Term(s)
Lipoprotein-Associated Phospholipase A(2)
Lipoprotein-Associated Phospholipase A2
Lp-PLA(2)
Lp-PLA2
PAF 2-Acetylhydrolase
PAF 2-Acylhydrolase
PAF Acetylhydrolase
PAF Acetylhydrolase II
Platelet-Activating Factor Hydrolase
Platelet-activating Factor Acetylhydrolase IB
Registry Number
EC 3.1.1.47
Related Numbers
EC 3.1.1.47
Previous Indexing
Phospholipases (1983-2003)
Public MeSH Note
2004; 1-ALKYL-2-ACETYLGLYCEROLPHOSPHOCHOLINE ESTERASE was indexed under PHOSPHOLIPASES A 1983-2003; LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 was indexed under PHOSPHOLIPASES A 2000-2007 & under 1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE 2007
History Note
2004(1983)
Date Established
2004/01/01
Date of Entry
2003/07/09
Revision Date
2013/07/08
1-Alkyl-2-acetylglycerophosphocholine Esterase Preferred
Platelet-activating Factor Acetylhydrolase IB Narrower
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