MeSH Browser

MeSH Heading: 1-Alkyl-2-acetylglycerophosphocholine Esterase
Tree Number(s): D08.811.277.352.100.680.750.937.249
Unique ID: D043203
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D043203
Annotation: /antag: coordinate with PHOSPHOLIPASE A2 INHIBITORS
Scope Note: A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Entry Term(s): Lipoprotein-Associated Phospholipase A(2); Lipoprotein-Associated Phospholipase A2; Lp-PLA(2); Lp-PLA2; PAF 2-Acetylhydrolase; PAF 2-Acylhydrolase; PAF Acetylhydrolase; PAF Acetylhydrolase II; Platelet-Activating Factor Hydrolase; Platelet-activating Factor Acetylhydrolase IB
Related Numbers: EC 3.1.1.47
Previous Indexing: Phospholipases (1983-2003)
Public MeSH Note: 2004; 1-ALKYL-2-ACETYLGLYCEROLPHOSPHOCHOLINE ESTERASE was indexed under PHOSPHOLIPASES A 1983-2003; LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 was indexed under PHOSPHOLIPASES A 2000-2007 & under 1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE 2007
History Note: 2004(1983)
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Carboxylic Ester Hydrolases [D08.811.277.352.100]
        
        Phospholipases [D08.811.277.352.100.680]
        
        Phospholipases A [D08.811.277.352.100.680.750]
        
        Phospholipases A2 [D08.811.277.352.100.680.750.937]
        
        1-Alkyl-2-acetylglycerophosphocholine Esterase [D08.811.277.352.100.680.750.937.249]
        
        Phospholipases A2, Calcium-Independent [D08.811.277.352.100.680.750.937.300]
        
        Phospholipases A2, Cytosolic [D08.811.277.352.100.680.750.937.625]
        
        Phospholipases A2, Secretory [D08.811.277.352.100.680.750.937.750]

1-Alkyl-2-acetylglycerophosphocholine Esterase Preferred

Concept UI: M0118406
Related Numbers: EC 3.1.1.47
Scope Note: A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Terms: 1-Alkyl-2-acetylglycerophosphocholine Esterase Preferred Term
Term UI T148410
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); PAF Acetylhydrolase II
Term UI T148406
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); Platelet-Activating Factor Hydrolase
Term UI T148408
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Lipoprotein-Associated Phospholipase A(2)
Term UI T414161
Date05/12/2000
LexicalTag NON
ThesaurusID NLM (2008); Lipoprotein-Associated Phospholipase A2
Term UI T414162
Date05/12/2000
LexicalTag NON
ThesaurusID NLM (2008); Lp-PLA(2)
Term UI T414164
Date05/12/2000
LexicalTag NON
ThesaurusID NLM (2008); Lp-PLA2
Term UI T414163
Date05/12/2000
LexicalTag NON
ThesaurusID NLM (2008); PAF 2-Acetylhydrolase
Term UI T148403
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); PAF Acetylhydrolase
Term UI T148405
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); PAF 2-Acylhydrolase
Term UI T148404
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004)

Platelet-activating Factor Acetylhydrolase IB Narrower

1-Alkyl-2-acetylglycerophosphocholine Esterase MeSH Descriptor Data 2024