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11-beta-Hydroxysteroid Dehydrogenase Type 2 MeSH Descriptor Data 2022


MeSH Heading
11-beta-Hydroxysteroid Dehydrogenase Type 2
Tree Number(s)
D08.811.682.047.436.174.600
D08.811.682.047.820.100.600
Unique ID
D043209
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D043209
Scope Note
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Entry Term(s)
11 beta-HSD2
11 beta-Hydroxysteroid Dehydrogenase Type 2
11beta-HSD2
11beta-HSD2 Reductase
11beta-Hydroxysteroid Dehydrogenase Type 2
Registry Number
EC 1.1.1.146
Previous Indexing
Hydroxysteroid Dehydrogenases (1992-2003)
Public MeSH Note
2004; 11 BETA-HSD2 was indexed under HYDROXYSTEROID DEHYDROGENASES 1992-2003
History Note
2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003
Entry Combination
deficiency:Mineralocorticoid Excess Syndrome, Apparent
Date Established
2004/01/01
Date of Entry
2003/07/09
Revision Date
2013/07/08
11-beta-Hydroxysteroid Dehydrogenase Type 2 Preferred
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