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An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. Leucine dehydrogenase catalyzes the reversible oxidative deamination of L-LEUCINE, to 4-methyl-2-oxopentanoate (2-ketoisocaproate) and AMMONIA, with the corresponding reduction of the cofactor NAD+.
Entry Term(s)
L-Leucine Dehydrogenase
Leucine (Branched-Chain Amino Acid) Dehydrogenase
Registry Numbers
EC 1.4.1.9
Related Numbers
9082-71-7
Previous Indexing
Amino Acid Oxidoreductases (1970-2005)
Leucine (1970-1979)
Public MeSH Note
2006; LEUCINE DEHYDROGENASE was indexed under AMINO ACID OXIDOREDUCTASES 1970-2005 & LEUCINE 1970-1982
An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. Leucine dehydrogenase catalyzes the reversible oxidative deamination of L-LEUCINE, to 4-methyl-2-oxopentanoate (2-ketoisocaproate) and AMMONIA, with the corresponding reduction of the cofactor NAD+.