NLM Logo

Pre-B Cell Receptors MeSH Descriptor Data 2023


MeSH Heading
Pre-B Cell Receptors
Tree Number(s)
D12.776.124.790.651.950.750
D12.776.377.715.548.950.750
D12.776.543.750.705.816.821.750
Unique ID
D054420
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054420
Scope Note
Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.
Entry Term(s)
Pre-B Cell Receptor
Registry Number
0
Previous Indexing
Receptors, Antigen, B-Cell (1995-2007)
Public MeSH Note
2008
History Note
2008
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2017/06/30
Pre-B Cell Receptors Preferred
page delivered in 0.362s