MeSH Browser

MeSH Heading: Thyrotropin Alfa
Tree Number(s): D06.472.699.631.525.883.374
Unique ID: D057073
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D057073
Scope Note: A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
Entry Term(s): Recombinant Human TSH; Thyrogen; rhTSH
Previous Indexing: Glycoprotein Hormones, alpha Subunit (1991-2009)
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0534260
Scope Note: A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
Terms: Thyrotropin Alfa Preferred Term
Term UI T748536
Date04/01/2009
LexicalTag NON
ThesaurusID NLM (2010); rhTSH
Term UI T780815
Date11/18/2010
LexicalTag ACR
ThesaurusID NLM (2012); Recombinant Human TSH
Term UI T780816
Date11/18/2010
LexicalTag ACX
ThesaurusID NLM (2012)

Thyrotropin Alfa MeSH Descriptor Data 2024