MeSH Browser

MeSH Heading: Serotonin
Tree Number(s): D02.092.211.215.801.852; D03.633.100.473.914.814; D23.469.050.650
Unique ID: D012701
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012701
Annotation: /antag = SEROTONIN ANTAGONISTS but consider also SELECTIVE SEROTONIN REUPTAKE INHIBITORS
Scope Note: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Entry Term(s): 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; Enteramine; Hippophaine; Hydroxytryptamine
Pharm Action: Serotonin Receptor Agonists
Registry Numbers: 333DO1RDJY; 0
Related Numbers: 50-67-9
CAS Type 1 Name: 1H-Indol-5-ol, 3-(2-aminoethyl)-
NLM Classification #: QV 126
See Also: Receptors, Serotonin; Serotonin Agents; Serotonin Syndrome
Public MeSH Note: HYDROXYTRYPTAMINE was see SEROTONIN 1975-92
Online Note: use SEROTONIN to search HYDROXYTRYPTAMINE 1975-92
History Note: HYDROXYTRYPTAMINE was see SEROTONIN 1975-92
Entry Combination: agonists:Serotonin Receptor Agonists; antagonists & inhibitors:Serotonin Antagonists
Date Established: 1960/01/01
Date of Entry: 1999/01/01
Revision Date: 2022/07/15

Entry Combination: agonists:Serotonin Receptor Agonists; antagonists & inhibitors:Serotonin Antagonists
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analogs & derivatives (AA)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Amines [D02.092]
  - Biogenic Amines [D02.092.211]
    - Biogenic Monoamines [D02.092.211.215]
      - Tryptamines [D02.092.211.215.801]
        
        N,N-Dimethyltryptamine [D02.092.211.215.801.451]
        
        Serotonin [D02.092.211.215.801.852]
        
        5-Methoxytryptamine [D02.092.211.215.801.852.611]

Heterocyclic Compounds [D03]
- Heterocyclic Compounds, Fused-Ring [D03.633]
  - Heterocyclic Compounds, 2-Ring [D03.633.100]
    - Indoles [D03.633.100.473]
      - Tryptamines [D03.633.100.473.914]
        
        Dihydroxytryptamines [D03.633.100.473.914.201]
        
        N,N-Dimethyltryptamine [D03.633.100.473.914.237]
        
        Melatonin [D03.633.100.473.914.481]
        
        Psilocybin [D03.633.100.473.914.700]
        
        Serotonin [D03.633.100.473.914.814]
        
        Bufotenin [D03.633.100.473.914.814.150]
        
        5-Methoxytryptamine [D03.633.100.473.914.814.400]
        
        Sumatriptan [D03.633.100.473.914.907]

Biological Factors [D23]
- Inflammation Mediators [D23.469]
  - Autacoids [D23.469.050]

Serotonin Preferred

Concept UI: M0019683
Registry Numbers: 333DO1RDJY
Related Numbers: 50-67-9
Scope Note: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Terms: Serotonin Preferred Term
Term UI T037552
Date01/01/1999
LexicalTag NON
ThesaurusID; 5-HT
Term UI T037550
Date05/28/1976
LexicalTag ABB
ThesaurusID UNK (19XX); 5-Hydroxytryptamine
Term UI T037551
Date04/05/1992
LexicalTag NON
ThesaurusID; 3-(2-Aminoethyl)-1H-indol-5-ol
Term UI T037553
Date11/30/1995
LexicalTag NON
ThesaurusID; Enteramine
Term UI T037554
Date04/03/1998
LexicalTag NON
ThesaurusID; Hippophaine
Term UI T037555
Date04/03/1998
LexicalTag NON
ThesaurusID NLM (1999)

Hydroxytryptamine Related

Serotonin MeSH Descriptor Data 2024