MeSH Browser

MeSH Heading: Histamine H1 Antagonists
Tree Number(s): D27.505.519.625.375.425.400; D27.505.696.577.375.425.400
Unique ID: D006634
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006634
Annotation: HISTAMINE H1 ANTAGONISTS, NON-SEDATING is also available
Scope Note: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Entry Version: HISTAMINE H1 ANTAG
Entry Term(s): Antagonists, Histamine H1; Antagonists, Histamine H1 Receptor; Antihistamines, Classical; Antihistamines, Sedating; Antihistaminics, Classical; Antihistaminics, H1; Blockaders, Histamine H1 Receptor; First Generation H1 Antagonists; H1 Receptor Blockaders; Histamine H1 Antagonist; Histamine H1 Blockers; Histamine H1 Receptor Antagonist; Histamine H1 Receptor Antagonists; Histamine H1 Receptor Blockaders; Receptor Blockaders, H1
NLM Classification #: QV 157
See Also: Anti-Allergic Agents; Bronchodilator Agents; Hypersensitivity, Immediate
Public MeSH Note: 95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90
Online Note: use HISTAMINE H1 ANTAGONISTS to search HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94 and ANTIHISTAMINICS 1966-76
History Note: 95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90
Date Established: 1977/01/01
Date of Entry: 1976/05/05
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Neurotransmitter Agents [D27.505.519.625]
      - Histamine Agents [D27.505.519.625.375]
        
        Histamine Antagonists [D27.505.519.625.375.425]
        
        Histamine H1 Antagonists [D27.505.519.625.375.425.400]
        
        Histamine H1 Antagonists, Non-Sedating [D27.505.519.625.375.425.400.500]
        
        Histamine H2 Antagonists [D27.505.519.625.375.425.425]
        
        Histamine H3 Antagonists [D27.505.519.625.375.425.712]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Neurotransmitter Agents [D27.505.696.577]
      - Histamine Agents [D27.505.696.577.375]
        
        Histamine Antagonists [D27.505.696.577.375.425]
        
        Histamine H1 Antagonists [D27.505.696.577.375.425.400]
        
        Histamine H1 Antagonists, Non-Sedating [D27.505.696.577.375.425.400.500]
        
        Histamine H2 Antagonists [D27.505.696.577.375.425.425]
        
        Histamine H3 Antagonists [D27.505.696.577.375.425.712]

Histamine H1 Antagonists Preferred

Concept UI: M0010395
Scope Note: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Terms: Histamine H1 Antagonists Preferred Term
Term UI T019977
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Receptor Blockaders, H1
Term UI T019969
Date11/20/1989
LexicalTag NON
ThesaurusID NLM (1990); Histamine H1 Antagonist
Term UI T001089188
Date09/28/2020
LexicalTag NON
ThesaurusID NLM (2022); Histamine H1 Receptor Antagonist
Term UI T001089189
Date09/28/2020
LexicalTag NON
ThesaurusID NLM (2022); Antagonists, Histamine H1
Term UI T019976
Date05/03/1994
LexicalTag NON
ThesaurusID NLM (1995); Antagonists, Histamine H1 Receptor
Term UI T019974
Date05/03/1994
LexicalTag NON
ThesaurusID NLM (1995); Antihistaminics, H1
Term UI T019973
Date05/01/1990
LexicalTag NON
ThesaurusID NLM (1991); Blockaders, Histamine H1 Receptor
Term UI T019970
Date05/03/1994
LexicalTag NON
ThesaurusID NLM (1995); H1 Receptor Blockaders
Term UI T019968
Date02/10/1984
LexicalTag NON
ThesaurusID UNK (19XX); Histamine H1 Blockers
Term UI T019979
Date01/28/1994
LexicalTag NON
ThesaurusID NLM (1995); Histamine H1 Receptor Blockaders
Term UI T019971
Date01/28/1994
LexicalTag NON
ThesaurusID NLM (1995); Histamine H1 Receptor Antagonists
Term UI T019975
Date03/30/1992
LexicalTag NON
ThesaurusID NLM (1993)

Antihistamines, Classical Narrower

Concept UI: M0503956
Terms: Antihistamines, Classical Preferred Term
Term UI T019978
Date03/29/1994
LexicalTag NON
ThesaurusID NLM (1995); Antihistamines, Sedating
Term UI T721916
Date07/03/2008
LexicalTag NON
ThesaurusID NLM (2009); Antihistaminics, Classical
Term UI T019972
Date04/23/1990
LexicalTag NON
ThesaurusID NLM (1991); First Generation H1 Antagonists
Term UI T686140
Date11/16/2006
LexicalTag NON
ThesaurusID NLM (2008)

Histamine H1 Antagonists MeSH Descriptor Data 2024