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Histamine H1 Antagonists, Non-Sedating MeSH Descriptor Data 2022


MeSH Heading
Histamine H1 Antagonists, Non-Sedating
Tree Number(s)
D27.505.519.625.375.425.400.500
D27.505.696.577.375.425.400.500
Unique ID
D039563
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039563
Scope Note
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Entry Version
HISTAMINE H1 ANTAG NON SEDATING
Entry Term(s)
H1 Antihistamines, Non-Sedating
Second Generation Antihistamine
Second Generation Antihistamines
Second Generation H1 Antagonist
Second Generation H1 Antagonists
Third Generation H1 Antagonist
Third Generation H1 Antagonists
Registry Number
0
Previous Indexing
Benzhydryl Compounds (1982-2002)
Histamine H1 Antagonists (1982-2002)
See Also
Anti-Allergic Agents
Public MeSH Note
2003
History Note
2003
Date Established
2003/01/01
Date of Entry
2002/07/02
Revision Date
2020/05/27
Histamine H1 Antagonists, Non-Sedating Preferred
Third Generation H1 Antagonists Narrower
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