MeSH Browser

MeSH Heading: Histamine H1 Antagonists, Non-Sedating
Tree Number(s): D27.505.519.625.375.425.400.500; D27.505.696.577.375.425.400.500
Unique ID: D039563
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039563
Scope Note: A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Entry Version: HISTAMINE H1 ANTAG NON SEDATING
Entry Term(s): H1 Antihistamines, Non-Sedating; Second Generation Antihistamine; Second Generation Antihistamines; Second Generation H1 Antagonist; Second Generation H1 Antagonists; Third Generation H1 Antagonist; Third Generation H1 Antagonists
Previous Indexing: Benzhydryl Compounds (1982-2002); Histamine H1 Antagonists (1982-2002)
See Also: Anti-Allergic Agents
Public MeSH Note: 2003
History Note: 2003
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0419330
Scope Note: A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Terms: Histamine H1 Antagonists, Non-Sedating Preferred Term
Term UI T488201
Date04/01/2002
LexicalTag NON
ThesaurusID NLM (2003); Second Generation H1 Antagonist
Term UI T000997693
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); H1 Antihistamines, Non-Sedating
Term UI T488202
Date04/01/2002
LexicalTag NON
ThesaurusID NLM (2003); Second Generation Antihistamines
Term UI T494686
Date05/20/2002
LexicalTag NON
ThesaurusID NLM (2003); Second Generation H1 Antagonists
Term UI T494685
Date05/20/2002
LexicalTag NON
ThesaurusID NLM (2003); Second Generation Antihistamine
Term UI T000997692
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021)

Histamine H1 Antagonists, Non-Sedating MeSH Descriptor Data 2024