NLM Logo

Fibroblast Growth Factor 2 MeSH Descriptor Data 2022


MeSH Heading
Fibroblast Growth Factor 2
Tree Number(s)
D12.644.276.624.120
D12.776.467.624.120
D23.529.624.120
Unique ID
D016222
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016222
Scope Note
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Entry Term(s)
Basic Fibroblast Growth Factor
Cartilage-Derived Growth Factor
Class II Heparin-Binding Growth Factor
FGF-2
FGF2
Fibroblast Growth Factor, Basic
Fibroblast Growth Factor-2
HBGF-2
Heparin-Binding Growth Factor Class II
Prostate Epithelial Cell Growth Factor
Prostatropin
Registry Number
103107-01-3
Previous Indexing
Fibroblast Growth Factor (1984-1990)
Growth Substances (1974-1983)
Public MeSH Note
2001; FIBROBLAST GROWTH FACTOR-2 was indexed under FIBROBLAST GROWTH FACTOR, BASIC 1996-2001 & under FIBROBLAST GROWTH FACTOR 1995; PROSTATROPIN was indexed under NERVE TISSUE PROTEINS 1986-2001; CARTILAGE-DERIVED GROWTH FACTOR was indexed under PROTEINS 2005-2006
History Note
2001(1991); for FIBROBLAST GROWTH FACTOR-2 use FIBROBLAST GROWTH FACTOR 2 (NM) 1995; for PROSTATROPIN use FIBROBLAST GROWTH FACTOR 2 (NM) 1986-2001
Date Established
1991/01/01
Date of Entry
1990/06/28
Revision Date
2013/07/09
Fibroblast Growth Factor 2 Preferred
page delivered in 0.145s