MeSH Browser

MeSH Heading: Fibroblast Growth Factor 1
Tree Number(s): D12.644.276.624.110; D12.776.467.624.110; D23.529.624.110
Unique ID: D016220
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016220
Scope Note: A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
Entry Term(s): Acidic Fibroblast Growth Factor; Class I Heparin-Binding Growth Factor; FGF-1; FGF1; Fibroblast Growth Factor, Acidic; Fibroblast Growth Factor-1; HBGF-1; Heparin-Binding Fibroblast Growth Factor Class I; Heparin-Binding Growth Factor, Class I
Registry Number: 104781-85-3
CAS Type 1 Name: Fibroblast growth factor (human brain acidic protein moiety reduced)
Previous Indexing: Fibroblast Growth Factor (1984-1990); Growth Substances (1974-1983)
Public MeSH Note: 2002; FIBROBLAST GROWTH FACTOR-1 was indexed under FIBROBLAST GROWTH FACTOR ACIDIC 2001, FIBROBLAST GROWTH FACTOR 2000-2001 & under FIBROBLAST GROWTH FACTOR, BASIC 1998-2000
History Note: 2002(1991); for FIBROBLAST GROWTH FACTOR-1 use FIBROBLAST GROWTH FACTOR 1(NM) 1998-2001
Date Established: 1991/01/01
Date of Entry: 1990/07/05
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Fibroblast Growth Factors [D12.644.276.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Fibroblast Growth Factors [D12.776.467.624]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Fibroblast Growth Factors [D23.529.624]

Fibroblast Growth Factor 1 Preferred

Concept UI: M0024768
Registry Number: 104781-85-3
Scope Note: A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
Terms: Fibroblast Growth Factor 1 Preferred Term
Term UI T440828
Date03/27/2001
LexicalTag NON
ThesaurusID NLM (2002); HBGF-1
Term UI T048285
Date03/01/1990
LexicalTag ACR
ThesaurusID NLM (1991); Heparin-Binding Fibroblast Growth Factor Class I
Term UI T048286
Date03/01/1990
LexicalTag NON
ThesaurusID NLM (1991); Heparin-Binding Growth Factor, Class I
Term UI T048282
Date03/01/1990
LexicalTag NON
ThesaurusID NLM (1991); Fibroblast Growth Factor, Acidic
Term UI T048284
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Fibroblast Growth Factor-1
Term UI T326075
LexicalTag NON
ThesaurusID NLM (2002); Class I Heparin-Binding Growth Factor
Term UI T048281
Date03/01/1990
LexicalTag NON
ThesaurusID NLM (1991); FGF-1
Term UI T326073
LexicalTag ACR
ThesaurusID NLM (2002); FGF1
Term UI T326074
LexicalTag ACR
ThesaurusID NLM (2002); Acidic Fibroblast Growth Factor
Term UI T048283
Date03/01/1990
LexicalTag NON
ThesaurusID NLM (1991)

Fibroblast Growth Factor 1 MeSH Descriptor Data 2024