MeSH Browser

MeSH Heading: Fibroblast Growth Factor 2
Tree Number(s): D12.644.276.624.120; D12.776.467.624.120; D23.529.624.120
Unique ID: D016222
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016222
Scope Note: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Entry Term(s): Basic Fibroblast Growth Factor; Cartilage-Derived Growth Factor; Class II Heparin-Binding Growth Factor; FGF-2; FGF2; Fibroblast Growth Factor, Basic; Fibroblast Growth Factor-2; HBGF-2; Heparin-Binding Growth Factor Class II; Prostate Epithelial Cell Growth Factor; Prostatropin
Previous Indexing: Fibroblast Growth Factor (1984-1990); Growth Substances (1974-1983)
Public MeSH Note: 2001; FIBROBLAST GROWTH FACTOR-2 was indexed under FIBROBLAST GROWTH FACTOR, BASIC 1996-2001 & under FIBROBLAST GROWTH FACTOR 1995; PROSTATROPIN was indexed under NERVE TISSUE PROTEINS 1986-2001; CARTILAGE-DERIVED GROWTH FACTOR was indexed under PROTEINS 2005-2006
History Note: 2001(1991); for FIBROBLAST GROWTH FACTOR-2 use FIBROBLAST GROWTH FACTOR 2 (NM) 1995; for PROSTATROPIN use FIBROBLAST GROWTH FACTOR 2 (NM) 1986-2001
Date Established: 1991/01/01
Date of Entry: 1990/06/28
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Fibroblast Growth Factors [D12.644.276.624]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Fibroblast Growth Factors [D12.776.467.624]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Fibroblast Growth Factors [D23.529.624]

Fibroblast Growth Factor 2 Preferred

Concept UI: M0024770
Scope Note: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Terms: Fibroblast Growth Factor 2 Preferred Term
Term UI T280762
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Basic Fibroblast Growth Factor
Term UI T048292
Date03/05/1990
LexicalTag NON
ThesaurusID NLM (1991); Class II Heparin-Binding Growth Factor
Term UI T048294
Date03/01/1990
LexicalTag NON
ThesaurusID NLM (1991); Heparin-Binding Growth Factor Class II
Term UI T048295
Date03/29/1990
LexicalTag NON
ThesaurusID NLM (1991); Prostate Epithelial Cell Growth Factor
Term UI T170248
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Prostatropin
Term UI T170249
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); FGF-2
Term UI T280760
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); FGF2
Term UI T280761
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2002); Fibroblast Growth Factor, Basic
Term UI T048293
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Fibroblast Growth Factor-2
Term UI T280763
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Cartilage-Derived Growth Factor
Term UI T642057
Date06/03/2005
LexicalTag NON
ThesaurusID NLM (2007); HBGF-2
Term UI T048296
Date03/01/1990
LexicalTag ABB
ThesaurusID NLM (1991)

Fibroblast Growth Factor 2 MeSH Descriptor Data 2024