MeSH Browser

MeSH Heading: Cyclin-Dependent Kinase 6
Tree Number(s): D08.811.913.696.620.682.700.646.500.937; D12.776.167.200.515; D12.776.476.563.646.500.937
Unique ID: D051361
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051361
Scope Note: Cyclin-dependent kinase 6 associates with CYCLIN D and phosphorylates RETINOBLASTOMA PROTEIN during G1 PHASE of the CELL CYCLE. It helps regulate the transition to S PHASE and its kinase activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P18.
Entry Term(s): CDK6 Protein; Cdk6 Protein Kinase; Cell Division Protein Kinase 6; PLSTIRE Protein
Public MeSH Note: 2006; CYCLIN-DEPENDENT KINASE 6 was indexed under CYCLIN-DEPENDENT KINASES 2003-2005, & under PROTEIN-SERINE-THREONINE KINASES 1995-2002, & under PROTEIN KINASES 1994
History Note: 2006(1994)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0228003
Scope Note: Cyclin-dependent kinase 6 associates with CYCLIN D and phosphorylates RETINOBLASTOMA PROTEIN during G1 PHASE of the CELL CYCLE. It helps regulate the transition to S PHASE and its kinase activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P18.
Terms: Cyclin-Dependent Kinase 6 Preferred Term
Term UI T258007
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); CDK6 Protein
Term UI T258008
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); PLSTIRE Protein
Term UI T629643
Date02/03/2005
LexicalTag ACX
ThesaurusID NLM (2006); Cdk6 Protein Kinase
Term UI T634008
Date03/22/2005
LexicalTag ABX
ThesaurusID NLM (2006); Cell Division Protein Kinase 6
Term UI T735194
Date02/17/2009
LexicalTag NON
ThesaurusID NLM (2010)

Cyclin-Dependent Kinase 6 MeSH Descriptor Data 2024