Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Cyclin-Dependent Kinase 4 MeSH Descriptor Data 2025


MeSH Heading
Cyclin-Dependent Kinase 4
Tree Number(s)
D08.811.913.696.620.682.700.646.500.875
D12.776.167.200.451
D12.776.476.563.646.500.875
Unique ID
D051358
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051358
Scope Note
Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16.
Entry Term(s)
Cdk4 Cyclin-Dependent Kinase
Cdk4 Protein
Cdk4 Protein Kinase
Cell Division Protein Kinase 4
Cyclin D-Dependent Kinase CDK4
PSK-J3 Kinase
p34PSK-J3 Kinase
Registry Numbers
EC 2.7.11.22
Public MeSH Note
2006; CYCLIN-DEPENDENT KINASE 4 was indexed under CYCLIN-DEPENDENT KINASES & PROTO-ONCOGENE PROTEINS 2005, CELL CYCLE PROTEINS 1992-2004, PROTEIN SERINE THREONINE KINASES 1995, & under PROTEIN KINASES 1992-1994
History Note
2006(1992)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2021/05/21
Cyclin-Dependent Kinase 4 Preferred
page delivered in 0.14s