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Maturation-Promoting Factor MeSH Descriptor Data 2022


MeSH Heading
Maturation-Promoting Factor
Tree Number(s)
D08.811.913.696.620.682.700.646.500.984
D12.776.167.200.580
D12.776.476.563.646.500.984
Unique ID
D016200
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016200
Scope Note
Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
Entry Version
MPF
Entry Term(s)
Histone H1 Kinase, Growth-Associated
Histone H1 Kinase, M-Phase-Specific
M Phase-Promoting Factor
Mitosis-Promoting Factor
Registry Number
EC 2.7.11.22
Previous Indexing
Growth Substances (1979-1990)
See Also
Cyclins
Public MeSH Note
91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93
History Note
91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93
Date Established
1991/01/01
Date of Entry
1990/06/17
Revision Date
2021/05/21
Maturation-Promoting Factor Preferred
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