MeSH Browser

MeSH Heading: Cyclin-Dependent Kinase Inhibitor p16
Tree Number(s): D12.644.360.225.200; D12.776.167.187.200; D12.776.476.225.200; D12.776.624.776.355.200
Unique ID: D019941
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019941
Scope Note: A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
Entry Term(s): CDKN2 Protein; CDKN2A Protein; Cdk4-Associated Protein p16; Cyclin-Dependent Kinase Inhibitor-2A; INK4A Protein; MTS1 Protein; Multiple Tumor Suppressor-1; p16(INK4A); p16INK4 Protein; p16INK4A Protein
Previous Indexing: Carrier Proteins (1994-1997)
See Also: Genes, p16; Tumor Suppressor Protein p14ARF
Public MeSH Note: 1998; see PROTEIN P16; CDK4-ASSOCIATED PROTEIN P16 was indexed under CARRIER PROTEINS 1994-1997; P16(INK4A) was indexed under CARRIER PROTEINS 2000-2001
History Note: 2006(1994)
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cell Cycle Proteins [D12.776.167]
    - Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.167.187]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Tumor Suppressor Proteins [D12.776.624.776]
      - Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]
        
        Cyclin-Dependent Kinase Inhibitor p15 [D12.776.624.776.355.100]
        
        Cyclin-Dependent Kinase Inhibitor p16 [D12.776.624.776.355.200]
        
        Cyclin-Dependent Kinase Inhibitor p18 [D12.776.624.776.355.300]
        
        Cyclin-Dependent Kinase Inhibitor p19 [D12.776.624.776.355.400]
        
        Cyclin-Dependent Kinase Inhibitor p21 [D12.776.624.776.355.500]
        
        Cyclin-Dependent Kinase Inhibitor p27 [D12.776.624.776.355.600]
        
        Cyclin-Dependent Kinase Inhibitor p57 [D12.776.624.776.355.700]

Cyclin-Dependent Kinase Inhibitor p16 Preferred

Concept UI: M0029615
Scope Note: A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
Terms: Cyclin-Dependent Kinase Inhibitor p16 Preferred Term
Term UI T623752
Date12/13/2004
LexicalTag NON
ThesaurusID NLM (2006); CDKN2 Protein
Term UI T059420
Date02/27/1997
LexicalTag NON
ThesaurusID NLM (1998); CDKN2A Protein
Term UI T059422
Date02/27/1997
LexicalTag NON
ThesaurusID NLM (1998); MTS1 Protein
Term UI T059424
Date02/27/1997
LexicalTag NON
ThesaurusID NLM (1998); p16INK4 Protein
Term UI T059428
Date02/27/1997
LexicalTag NON
ThesaurusID NLM (1998); Cdk4-Associated Protein p16
Term UI T059419
Date02/27/1997
LexicalTag NON
ThesaurusID NLM (1998); p16(INK4A)
Term UI T404411
Date01/06/2000
LexicalTag ABX
ThesaurusID NLM (2002); INK4A Protein
Term UI T404412
Date01/06/2000
LexicalTag ABX
ThesaurusID NLM (2002); Cyclin-Dependent Kinase Inhibitor-2A
Term UI T432636
Date01/09/2001
LexicalTag NON
ThesaurusID NLM (2002); Multiple Tumor Suppressor-1
Term UI T432643
Date01/09/2001
LexicalTag NON
ThesaurusID NLM (2002); p16INK4A Protein
Term UI T059429
Date02/27/1997
LexicalTag NON
ThesaurusID NLM (1998)

Cyclin-Dependent Kinase Inhibitor p16 MeSH Descriptor Data 2024