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Cyclin-Dependent Kinase Inhibitor p27 MeSH Descriptor Data 2022


MeSH Heading
Cyclin-Dependent Kinase Inhibitor p27
Tree Number(s)
D12.644.360.225.600
D12.776.167.187.600
D12.776.476.225.600
D12.776.624.776.355.600
Unique ID
D050760
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050760
Scope Note
A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
Entry Term(s)
CDK Inhibitor p27
CDKN1B Protein
CDKN4 Protein
Cyclin-Dependent Kinase Inhibitor 1B
p27 CDK Inhibitor
p27 Kip1 Protein
p27Kip1 Protein
Pharm Action
Protein Kinase Inhibitors
Registry Number
147604-94-2
Public MeSH Note
2006; CYCLIN-DEPENDENT KINASE INHIBITOR P27 was indexed under CELL CYCLE PROTEINS & TUMOR SUPPRESSOR PROTEINS 1992-2005
History Note
2006(1992)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2015/11/23
Cyclin-Dependent Kinase Inhibitor p27 Preferred
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