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Tumor Suppressor Protein p14ARF MeSH Descriptor Data 2025


MeSH Heading
Tumor Suppressor Protein p14ARF
Tree Number(s)
D12.776.167.600
D12.776.624.776.772
Unique ID
D025803
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D025803
Scope Note
A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
Entry Term(s)
Cdkn2a(p14ARF)
p(ARF) Protein
p14(ARF)
p14ARF
p14ARF Protein
Registry Numbers
0
See Also
Cyclin-Dependent Kinase Inhibitor p16
Genes, p16
Public MeSH Note
2002; TUMOR SUPPRESSOR PROTEIN P14ARF was indexed under P14ARF PROTEIN 2002-2005, & under PROTEINS 1996-2001
History Note
2002(1996)
Date Established
2002/01/01
Date of Entry
2001/07/25
Revision Date
2013/07/09
Tumor Suppressor Protein p14ARF Preferred
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