Smad4 Protein MeSH Descriptor Data 2024

MeSH Heading: Smad4 Protein
Tree Number(s): D12.644.360.024.334.750; D12.776.157.057.170.750; D12.776.260.713.750; D12.776.476.024.428.750; D12.776.624.776.760; D12.776.930.806.750
Unique ID: D051901
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051901
Scope Note: A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Entry Term(s): Common Smad; MADH4 Protein
Public MeSH Note: 2006; SMAD4 PROTEIN was indexed under DNA-BINDING PROTEINS & TRANS-ACTIVATORS 1997-2005, & under PROTEINS 1996
History Note: 2006(1996)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/02/18

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Smad Proteins [D12.644.360.024.334]
        
        Smad Proteins, Inhibitory [D12.644.360.024.334.200]
        
        Smad Proteins, Receptor-Regulated [D12.644.360.024.334.500]
        
        Smad4 Protein [D12.644.360.024.334.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Smad Proteins [D12.776.157.057.170]
        
        Smad Proteins, Inhibitory [D12.776.157.057.170.249]
        
        Smad Proteins, Receptor-Regulated [D12.776.157.057.170.500]
        
        Smad4 Protein [D12.776.157.057.170.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Smad Proteins [D12.776.260.713]
      - Smad Proteins, Receptor-Regulated [D12.776.260.713.500]
      - Smad4 Protein [D12.776.260.713.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Smad Proteins [D12.776.476.024.428]
        
        Smad Proteins, Inhibitory [D12.776.476.024.428.249]
        
        Smad Proteins, Receptor-Regulated [D12.776.476.024.428.500]
        
        Smad4 Protein [D12.776.476.024.428.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Tumor Suppressor Proteins [D12.776.624.776]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Smad Proteins [D12.776.930.806]

Smad4 Protein Preferred

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