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Tuberous Sclerosis Complex 1 Protein MeSH Descriptor Data 2022


MeSH Heading
Tuberous Sclerosis Complex 1 Protein
Tree Number(s)
D12.644.360.925
D12.776.476.932
D12.776.624.776.766
Unique ID
D000077004
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077004
Scope Note
An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.
Entry Term(s)
Hamartin
Registry Number
0
Public MeSH Note
2019; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2006-2018 and under PROTEINS 1997-2005
History Note
2019 (1997)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2019/04/29
Tuberous Sclerosis Complex 1 Protein Preferred
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